Post-Corona Analog | Introduction

Analog Intelligence.. Post Corona. In this Magazine Serie Article's inform the readers with the real deal. Scientifical research, mindfulness, body wellness and astrology, influenced with opinion and reminisce..

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Coronavirus spreads primarily through human-to-human infection, but weather may also play an important role. Viruses are particularly prevalent in winter. This is not only due to the fact that we live closer together in indoor spaces, where we infect each other more easily. How that works we explain in this article.

The fact that many people suffer from colds and flu in the autumn, winter and early spring is because our resistance is lower. Cold, strong wind, temperature changes and a lack of vitamin D make us more susceptible to viruses such as the common flu and the new coronavirus. Modeling of Protein Corona Introduction:

Nanoparticles have been studied for drug delivery and antitumor therapeutics.

Experimental and theoretical studies have mostly focused on modulating the size, struc-

ture, and surface properties of nanoparticles, in order to increase the targeting efficiency of

nanoparticles. However, when nanoparticles flow through the bloodstream, they

interact with various plasma proteins and, thus, their surfaces are often covered by multiple

protein layers, a process called protein corona. Abstract:The conformations and surface properties of nanoparticles have been modified to improve the efficiency of drug delivery. However, when nanoparticles flow through the bloodstream, they interact with various plasma proteins, leading to the formation of protein layers on the nanoparticle surface, called protein corona. Experiments have shown that protein corona modulates nanoparticle size, shape, and surface properties and, thus, influence the aggregation of nanoparticles and their interactions with cell membranes, which can increases or decreases the delivery efficiency. To complement these experimental findings and understand atomic-level phenomena that cannot be captured

by experiments, molecular dynamics (MD) simulations have been performed for the past decade. MD simulations have successfully predicted the competitive binding and conformation of protein corona and its effect on the nanoparticle–nanoparticle and nanoparticle–membrane interactions. In particular, simulations have uncovered the mechanism regarding the competitive adsorption and desorption of plasma proteins, which helps to explain the Vroman effect. Overall, these findings indicate that simulations can now provide predications in excellent agreement with experimental observations as well as atomic-scale insights into protein corona formation and interactions. The formation of protein corona

Influences, conformations and surface properties of nanoparticles, which can significantly increase or decrease the targeting efficiency and cytotoxicity via electrostatic and hydropho-

bic interactions between nanoparticles and cell membranes. The mechanism of the protein corona formation and the effect of protein corona on nanoparticle properties and interactions with cell membranes need to be studied at nearly the atomic scale.

nanoparticle complexed with plasma proteins for the past decade.. Dry air plays into the hands of viruses

In the winter, viruses know how to spread better than in the summer because the air contains less moisture. The colder the air the less moisture there can be in the air. Heating our homes makes the air even drier in proportion.

During a dry frost period the humidity outside is already low. In addition, we have to heat this air even more than average and we have to deal with very dry air in our homes. You notice this also by the fact that things become static and you suffer from dry hands and a dry mouth.

Dry air is bad for our health. Here are the consequences:

Your mucous membranes dry out and therefore viruses can enter your body more easily. Additionally, viruses stay alive longer in dry air. So a dry frost period promotes the spread of a virus.